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Scientists Say Anticancer Drug Imatinib Can Stop Morphine Tolerance

GEN News Highlights

February 20, 2012


A “tail” of opioid receptor variants.  Puig  S, Gutstein HB.  J Clin Invest. 2017 Apr 3;127(4):1221-1224. doi: 10.1172/JCI93582. Epub 2017 Mar 20.

Opioids: Keeping the good, eliminating the bad.  Puig  S, Gutstein HB.  Nature Medicine. 2017;  doi:10.1038/nm.4277.

Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics. Trang T, Al-Hasani R, Salvemini D, Salter MW, Gutstein H, Cahill CM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015; 35(41):13879-88.

Platelet-derived growth factor receptor-β antagonism restores morphine analgesic potency against neuropathic pain. Donica CL, Cui Y, Shi S, Gutstein HB. PloS one. 2014; 9(5):e97105.

Blockade of PDGFR-β activation eliminates morphine analgesic tolerance. Wang Y, Barker K, Shi S, Diaz M, Mo B, Gutstein HB. Nature medicine. 2012; 18(3):385-7. NIHMSID: NIHMS342900

Hedgehog signaling regulates nociceptive sensitization. Babcock DT, Shi S, Jo J, Shaw M, Gutstein HB, Galko MJ. Current biology : CB. 2011; 21(18):1525-33. NIHMSID: NIHMS347394

Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain. Shurman J, Koob GF, Gutstein HB. Pain medicine (Malden, Mass.). 2010; 11(7):1092-8. NIHMSID: NIHMS218055